High-resolution late gadolinium enhancement imaging with compressed sensing: a single-center clinical study

Background Late gadolinium enhancement (LGE) MRI is the clinical standard for imaging of scar in the left ventricle (LV). It has also been employed for assessing RF ablations in the left atrium (LA). LV LGE imaging is typically performed in 2D. When 3D is utilized, spatial resolution is limited due to prolonged scan time. We have shown that an accelerated imaging technique called LOST with random undersampling can be used to achieve isotropic resolution in 3D LGE. To benefit from this novel technique and the resolution gains, reconstruction needs to be automated and integrated into clinical workflow. In this study, we sought to utilize random undersampling and LOST reconstruction, with a novel software tool that enables clinically feasible integration, in order to enable LGE MRI with high isotropic spatial resolution in the clinical setting in a large cohort of patients.